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Glycopyrrolate and Iontoporesis

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PostPosted: Fri Feb 03, 2012 8:59 pm    Post subject: Glycopyrrolate and Iontoporesis Reply with quote

General Information to Glycopyrrolate and Iontoporesis

Glycopyrrolate is a drug that as the aibility to suppress excessive sweating, the symptom of hyperidrosis.
Glycopyrrolate normally it is taken orally administered.
Glycopyrrolate can be brought into the body with iontophoresis, tis is called medical iontophoresis too. Some do not get a really satisfying results with ionto, before taking the operation or ETS option, maybe it is worth to give Iontoporesis in conjunction wit Glycopyrrolate a trial. This special iontophoresis purpose is (different to tap water iontoporesis) indicated, allocated, controlled and prescribed by your dermatologist or doctor.

The good news what Glycopyrrolate can be dissolved in water and brought into the skin via Iontoporesis. The more good news is, that possible side effects of the drug Glycopyrrolate in conjunction with Iontoporesis to treat excessive sweating, are in many cases not so serious (or milder, if any) than when taking it orally.
Why this? Easy thing: the Glycopyrrolate (when you do it the way it supposed to be) is brought in the upper skin area only, and is trough this the glycopyrrolate is not spreaded over the wole body.
To reach the same % the concentration in the upper skin, when taken it orally is much higher.
E.g.: When you only want to treat a area of 100 cm2 that weights only 50 gramms it does not really make sense to take it orally for a body weight of 80 kg, the math factor is 1: 4000
- if the side effects of the drug is suppressed by the same factor, you would have the 4000th part of the side effect when taken it orally.

Please keep in mind: We are no doctors, so these statements are only mathematic and cannot be really assigned into medical reality, for concrete medical information you should always ask your doctor

However Glycopyrrolate with Iontoporesis users can have the same (hopefully not in the same proportion) side effects, when taken it orally.

In fact - if it works - it does not only reduce excesive sweat, it has also contraindications that can be:
    dry eyes
    dry mucosa (mucous membrane), this is also very bad for women, cause vaginal fluid can be suppress too
    dry eyes
    too dry skin
    dry mouth
    decreased sweating in parts that should sweat
    vision problems like blurred vision
    the loss of taste
    nervousness
    confusioning drowsiness
    headaches
    weakness
    feeling of dizziness
    falling asleep or staying asleep
    upset stomach vomiting
    constipation bloated feeling

    Some uncommon side effects of Glycopyrrolate:
    diarrhea (case of trots)
    skin rash
    skin hives
    difficulty with breathing
    also if you swallow Glycopyrrolate, it may have other unwished side effects.

    In any case: Call your doctor immediately, if you have any unusual problems while taking this medication.


So far, now to the request:
First, why do they alter the polarity? this does not make any sense when the hand is still in the trays

In order to prevent systemic effects, a good support should keep an eye when systemic side effects occur. This can be a sign that theh drug is brought too deep in the body, so the factors

current strenght
drug concentration
treatmetn length

should be readjusted to the personal patient needs, the best is indeed the balance between these factors to allow the best lead to a treatment without (or as less as possible) side effects and a total sweat free effect
To begin, it is a good idea to set the mA in direct current mode to 2-5 mA or 4-10 volts, the time to 5 minutes (this is enough to get the glycon in the hands) and the concentration to 1 mg per litre

the prefect water height sould be coosed to the height the sweat goes to, if it is partial the areas that sould not get the glyco can be covered before treatmetn with a good skin care ( www.current-care.info )

now it is important if the glyco is poled (on the med is there a + or - or neutral for iontophoresis)
if it is not, as i know that the normal glyco is neutral
you can place the glyco in both trays

a polarity switch only makes sense if the glyco is a poled one, the polarity change makes sense to make sure the glyco will go into the skin

if you do it in both trays the

there is a correspondance in how much you put in the trays (in mg) in how much water (in ml) with how much current (in mA) and the time (in minutes)
this factor describes how much will go how deep into the skin
there is more corrspondance at
the depth is more like the factor of time and current strength
the "how much" is more like the factor of glyco in how much water

ionto pushes any med or even homoepatic solutions deep into the skin, the longer you do it the more will "walk" into the body (and blood circulation)

you can e.g. drive voltaren depp into a joint by placing the voltaren gel at one side of the joint, then laying one pole over the area you ve placed the voltaren, the other at the opposite of the joint, if you treat to short the voltaren will be before the "inner" joint, if you treat right it will be in the joint and if you treat too long it will be in the skin under the other electrode


Quote:
Hi Markus

I have a question from the NHS regarding the PSP1000 and Glycopyrrolate... I checked the forum and could only find one post that did not answer the question I have...

On old machine, when using Glyco the staff only put solution in one tray and then switched polarity during the treatment apparently in order to prevent systemic problems of using Glyco for iontophoresis. As we do not alter polarity they are asking what they should do when treating patients with Glyco?

Can they place solution in both trays and perform treatment, or just one tray and switch half way through?

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Hyperhidrosis - excessive or extreme sweating is a common disorder.